Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development

Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development

Primary aldosteronism (PA) is the most common form of secondary hypertension with an estimated prevalence of ~10% in referred patients. PA occurs as a result of a dysregulation of the normal mechanisms controlling adrenal aldosterone production. It is characterized by hypertension with low plasma renin and elevated aldosterone and often associated with hypokalemia. The two major causes of PA ar...

Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.

The purpose of this study was to evaluate the DNA methylation levels of steroidogenic enzyme genes in aldosterone-producing adenoma (APA) and the effects of gene mutations in APA on the DNA methylation levels. DNA methylation array analysis was conducted using nonfunctioning adrenocortical adenoma (n=12) and APA (n=35) samples, including some with a KCNJ5 mutation (n=21), an ATP1A1 mutation (n=...

CTNNB1 Mutation in Aldosterone Producing Adenoma

Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outc...

[Laparoscopic partial adrenalectomy for aldosterone-producing adenoma].

O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma

لطفاً به چکیده انگلیسی مراجعه شود.